Zolpidem vs Melatonin
Prescription sleep medication versus natural sleep hormone for insomnia
Brands: Ambien
Drug Class
Sedative-HypnoticEffectiveness Rating
Safety Rating
Mechanism of Action
Selectively binds to GABA-A receptors to induce sleep
Common Uses
- Short-term insomnia treatment
Endogenous hormone
Research Quality
strongEffectiveness Rating
Safety Rating
Active Compounds
Modern Uses
- Insomnia
- Sleep disorders
- Jet lag
Zolpidem more effective for severe insomnia and sleep initiation. Melatonin best for circadian-related sleep issues and provides modest sleep benefits.
Zolpidem has dependence risk and unusual side effects (sleep-walking, etc). Melatonin very safe with minimal side effects.
Melatonin extremely affordable OTC. Zolpidem expensive and requires prescription and doctor visits.
Zolpidem requires prescription but works first night. Melatonin available OTC and ideal for travel or shift work.
Both well-researched. Zolpidem proven for insomnia. Melatonin strongest evidence for jet lag and circadian disorders.
Related Comparisons
Use zolpidem for severe insomnia when natural methods fail, short-term only. Choose melatonin for jet lag, circadian rhythm issues, mild insomnia, or long-term use.
⚠️ Medical Disclaimer
This comparison is for informational purposes only. Always consult with a qualified healthcare provider before making decisions about medications or supplements.