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St. John's Wort

Hypericum perforatum

Natural Remedystrong Research QualityWidely available as capsules and tablets

Effectiveness

4/10

Safety

3/10

Cost

2/10

How It Works

Inhibits reuptake of serotonin, dopamine, and norepinephrine

Active Compounds

Hypericin
Hyperforin
Flavonoids

Traditional Uses

Mild to moderate depression
Mood support
Anxiety

Modern Uses

Depression
Seasonal affective disorder
Mood disorders

Benefits

✓Natural antidepressant
✓Mood enhancement
✓Well-studied

Dosage Information

300mg standardized extract 3 times daily

Possible Side Effects

•Photosensitivity
•Dry mouth
•Dizziness
•Digestive upset

Important Warnings

⚠Many drug interactions
⚠May worsen bipolar disorder
⚠Takes 4-6 weeks to work

Interactions

This natural remedy may interact with the following:

•Antidepressants
•Birth control
•Blood thinners
•Many others

Pharmaceutical Comparisons

See how this natural remedy compares to conventional pharmaceutical treatments.

Fluoxetine

Prozac

SSRI antidepressant versus herbal alternative for depression management

SSRI

Other Depression Natural Remedies

5-HTP

Griffonia simplicifolia extract

moderate Research

Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. Natural remedies can interact with medications and may not be suitable for everyone. Always consult with a qualified healthcare provider before starting any new treatment, especially if you are pregnant, nursing, or taking medications.