Home/Sleep & Insomnia/Diphenhydramine

Diphenhydramine

Brand names: Benadryl, Unisom SleepGels

Antihistamine

Effectiveness

3/10

Safety

3/10

Cost

2/10

How It Works

Blocks histamine H1 receptors in the brain to cause sedation

Common Uses

Occasional insomnia
Allergies
Motion sickness

Dosage Information

25-50mg at bedtime for sleep

Common Side Effects

•Dry mouth
•Constipation
•Urinary retention
•Next-day grogginess

Important Warnings

⚠Tolerance develops quickly
⚠Cognitive impairment in elderly
⚠Anticholinergic effects

Drug Interactions

This medication may interact with the following:

•Alcohol
•Other anticholinergics
•MAOIs

Natural Alternatives

Explore evidence-based natural remedies that may offer similar benefits with different risk profiles.

Chamomile

Matricaria chamomilla

OTC antihistamine sleep aid versus traditional herbal tea for occasional sleep issues

Research: moderate

Other Sleep & Insomnia Medications

Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making changes to your medication regimen or trying natural alternatives.